USCAP Challenges in Hematopathology 2019

Hematopoietic neoplasms are highly heterogeneous, composed of numerous clinicopathologic subtypes and variants, and may present at many organ sites. The diagnostic evaluation of lymphomas and hematopoietic neoplasms presenting at nodal and extra-nodal sites requires careful integration of histologic, immunophenotypic, clinical and molecular features. Furthermore, rapid advances in the genetic/genomic understanding of these diseases pose a significant challenge to staying abreast of the diagnostic criteria, immunophenotypic and molecular prognostic/therapeutic markers that have clinical impact.

This is underscored by diminishing sample sizes in biopsies of extra-nodal lesions and needle core biopsies of lymph nodes. In addition, the role of the pathologist as integrators of information is expanding rapidly.

This educational activity will highlight practical aspects representing important changes that impact the diagnostic approach to challenging extra-nodal hematopoietic neoplasms, cutaneous lymphomas, T-cell lymphomas and needle core biopsies from lymph nodes.

Target Audience

Practicing academic and community pathologists, and pathologists-in-training

Learning Objectives

• Upon completion of this educational activity, learners will be able to:
• Develop diagnostic approaches to challenging extra-nodal hematopoietic neoplasms, cutaneous lymphomas, T-cell lymphomas and needle core biopsies from lymph nodes
• Facilitate better use of immunohistochemical and molecular studies to identify clinically relevant subtypes of cutaneous lymphomas and T-cell lymphomas
• Improve ability to distinguish the subtypes of T-cell lymphomas
• Refine skills to distinguish subtypes of hematopoietic neoplasms that present in extra-nodal sites
• Enhance capacity to evaluate lymphomas for clinically-relevant therapeutic targets

Items Included in the Purchase of this Course

• Challenging Extranodal Hematopoietic Neoplasms – Joseph Khoury, MD
• Cutaneous Lymphomas – Alejandro A. Gru, MD
• Challenging LN Needle Core Biopsies – Megan Lim, MD, PhD
• T Cell Lymphomas – Nathanael Bailey, MD
• Overview of the WHO Classification and Updates in the Revised 4th Edition – Elaine Jaffe, MD

Original release date: June 20, 2019