2026 Pathology Review: Practical Updates in Hematolymphoid, Genitourinary, and Orthopedic Pathology for the General Pathologist

Advance your diagnostic expertise with the 2026 Pathology Review: Practical Updates in Hematolymphoid, Genitourinary, and Orthopedic Pathology for the General Pathologist, a comprehensive CME-focused educational program designed specifically for practicing pathologists.

This in-depth course provides practical updates and case-based learning across three major pathology subspecialties: hematolymphoid pathology, genitourinary pathology, and orthopedic pathology. Through expert-led lectures and real-world diagnostic discussions, participants will learn to recognize critical pathological features, avoid common diagnostic pitfalls, and apply modern ancillary testing techniques including immunohistochemistry and molecular pathology.

The program features renowned pathology educators including Cristina Magi-Galluzzi, Kathryn Foucar, and John Reith, delivering practical insights for everyday diagnostic challenges encountered in surgical pathology and hematopathology practice.

What You’ll Learn:

• Identify benign mimickers and diagnostic pitfalls in prostate pathology
• Diagnose urothelial and renal neoplasms using morphology and ancillary testing
• Recognize myelodysplastic syndromes and myeloid neoplasms
• Approach acute myeloid leukemia using modern molecular concepts
• Diagnose lymphoid disorders in blood and bone marrow specimens
• Evaluate musculoskeletal lesions and orthopedic pathology specimens
• Improve frozen section interpretation in periprosthetic joint infection
• Distinguish benign and malignant cartilage and giant cell-rich bone tumors

Course Highlights:

• Comprehensive video lectures + downloadable PDF materials
• Practical, case-based diagnostic approach
• Focus on daily challenges faced by general pathologists
• Coverage of modern pathology updates and classification systems
• Emphasis on morphology, immunohistochemistry, and molecular diagnostics

Who Should Attend:

• Practicing pathologists
• General surgical pathologists
• Hematopathologists
• Pathology fellows and residents seeking practical review training

Key Topics Include:

• Prostate pathology and cribriform lesions
• Urothelial pathology and renal tumors
• Myelodysplasia and acute myeloid leukemia
• B-cell and T/NK-cell neoplasms
• Synovial and musculoskeletal pathology
• Arthroplasty pathology and joint infection diagnosis
• Bone and cartilage neoplasms

This course is ideal for pathologists seeking a practical diagnostic review and updated knowledge in modern hematolymphoid, GU, and orthopedic pathology.

Course Curriculum

Challenges and Controversies in Hematopathology: Classification Dilemmas in Search of Solutions

Modern hematopathology sits at the intersection of morphology, immunophenotyping, cytogenetics, and molecular genomics. As classification systems continue evolving and next-generation sequencing becomes increasingly integrated into routine diagnostics, pathologists are frequently confronted with cases that do not fit neatly into traditional diagnostic categories. The USCAP 2026 Long Course in Hematopathology addresses these realities directly through an advanced, case-based exploration of some of the most difficult classification dilemmas in contemporary hematopathology practice.

Released as part of the USCAP 2026 Annual Meeting educational program, this long course focuses on the practical integration of morphologic assessment, immunophenotypic interpretation, and molecular testing strategies to improve diagnostic precision in hematologic malignancies and related disorders.

This advanced educational package includes:

• Long Course Video Lectures
• Release Date: April 9, 2026
• Advanced Hematopathology Educational Content
• Case-Based Diagnostic Discussions

Rather than approaching hematopathology as a purely theoretical classification exercise, the course emphasizes the complex real-world diagnostic challenges encountered in both academic and community practice.

The Growing Complexity of Modern Hematopathology

Hematopathology has changed dramatically over the past decade. The rapid expansion of molecular diagnostics and genomic profiling has improved understanding of hematologic neoplasms but has also introduced increasing diagnostic complexity.

Today, diagnostic decision-making often requires simultaneous interpretation of:

• Histomorphology
• Flow cytometry
• Immunohistochemistry
• Cytogenetics
• Fluorescence in situ hybridization (FISH)
• Next-generation sequencing (NGS)
• Clinical presentation
• Disease evolution patterns

One recurring challenge involves cases with overlapping molecular and morphologic features that blur traditional diagnostic boundaries.

The course repeatedly emphasizes that classification systems continue evolving because disease biology itself is often more heterogeneous than rigid taxonomic categories suggest.

Integrating Molecular Diagnostics Into Routine Practice

A major focus of the program involves practical integration of genomic technologies into hematopathology workflows.

Topics include:

• Next-generation sequencing interpretation
• Molecular profiling strategies
• Genomic classification refinement
• Ancillary test selection
• Molecular-clinical correlation
• Cost-effective diagnostic workup design

The “Novel Genomic Technologies in Hematopathology” lecture provides a particularly useful framework for diagnostic pathologists navigating the expanding role of genomic testing in daily practice.

Importantly, the course does not present molecular testing as a replacement for morphology. Instead, it emphasizes how molecular data must be interpreted within the broader morphologic and clinical context.

Classification Challenges in Hematologic Neoplasia

One of the strongest aspects of the course is its focus on diagnostic ambiguity and classification controversy.

The sessions explore:

• Borderline hematologic entities
• Overlapping lymphoma categories
• Evolving WHO classification systems
• Diagnostic gray zones
• Rare neoplasms with heterogeneous features
• Clinically actionable subclassification strategies

In practice, hematopathologists frequently encounter cases where:

• Morphology is atypical
• Immunophenotypes are incomplete
• Molecular findings are nonspecific
• Disease categories overlap
• Classification systems remain in transition

The course appropriately acknowledges these realities while emphasizing structured diagnostic reasoning.

Histiocytic & Dendritic Neoplasms

The lecture on histiocytic and dendritic neoplasms reviews one of the more diagnostically challenging areas in hematopathology.

Topics include:

• Histiocytic proliferations
• Dendritic cell neoplasms
• Molecular alterations
• Differential diagnosis
• Immunophenotypic characterization

These entities are often difficult because of:

• Rarity
• Morphologic variability
• Overlap with inflammatory processes
• Limited standardized diagnostic frameworks

The session provides important updates regarding newer biologic and molecular insights that increasingly influence classification.

Pediatric Myelodysplastic Syndromes & Differential Diagnosis

Pediatric myelodysplastic syndromes represent another highly specialized and evolving area covered in the course.

The lecture examines:

• Pediatric MDS classification
• Bone marrow failure syndromes
• Germline predisposition disorders
• Differential diagnostic strategies
• Molecular abnormalities in pediatric disease

Pediatric hematopathology frequently requires different diagnostic considerations compared with adult disease because:

• Disease biology differs
• Germline syndromes are more relevant
• Morphologic interpretation may vary by age
• Classification criteria continue evolving

High-Grade B-Cell Lymphomas

The high-grade B-cell lymphoma session addresses one of the most clinically important and diagnostically complex lymphoma categories.

Topics include:

• Aggressive B-cell neoplasms
• Double-hit and triple-hit lymphomas
• Molecular subclassification
• Differential diagnosis
• Diagnostic algorithms
• Prognostic implications

Clinical decision-making becomes particularly important in these cases because diagnostic subclassification directly affects:

• Treatment intensity
• Prognostic assessment
• Eligibility for targeted therapies
• Clinical trial stratification

The course emphasizes practical diagnostic workflows for approaching aggressive B-cell proliferations.

Advances in Peripheral T-Cell Lymphomas

Peripheral T-cell lymphomas remain among the most heterogeneous and diagnostically difficult hematologic malignancies.

The lecture reviews:

• T-cell lymphoma classification updates
• Molecular profiling
• Immunophenotypic interpretation
• Differential diagnosis
• Emerging biologic insights

Many peripheral T-cell lymphomas demonstrate overlapping morphologic patterns, making integrated molecular and immunophenotypic assessment increasingly important.

Splenic B-Cell Lymphoma Classification

The splenic B-cell lymphoma lecture explores:

• Splenic marginal zone lymphoma
• Hairy cell leukemia variants
• Splenic diffuse red pulp lymphoma
• Classification refinements
• Diagnostic pitfalls

Splenic lymphoid neoplasms frequently present diagnostic difficulty because:

• Tissue sampling may be limited
• Morphology can overlap substantially
• Immunophenotypic profiles may not be entirely specific

The roadmap-style approach used in this lecture provides practical guidance for navigating these complex entities.

Case-Based Learning & Diagnostic Reasoning

A major educational strength of the course is its case-based structure.

The discussions repeatedly emphasize:

• Stepwise diagnostic reasoning
• Test selection strategy
• Morphologic interpretation
• Ancillary study integration
• Differential diagnosis development
• Clinical correlation

Case-based learning remains particularly valuable in hematopathology because real-world diagnostic practice rarely follows perfectly linear textbook patterns.

Practical Relevance for Modern Diagnostic Pathology

The course reflects the reality that hematopathologists today must increasingly function as integrative diagnosticians capable of synthesizing:

• Morphology
• Molecular pathology
• Clinical oncology
• Genomics
• Laboratory medicine

The educational focus remains grounded in practical application rather than purely academic classification theory.

What’s Included

• USCAP 2026 Long Course hematopathology lectures
• Advanced diagnostic pathology discussions
• Molecular hematopathology updates
• Case-based lymphoma and myeloid neoplasm reviews
• WHO classification and genomic integration topics
• Q&A educational section

Final Expert Perspective

Hematopathology continues evolving rapidly as molecular technologies reshape disease classification and deepen understanding of hematologic malignancies. Yet despite these advances, diagnostic uncertainty and classification controversy remain central challenges in daily practice.

The USCAP 2026 Long Course: Challenges and Controversies in Hematopathology provides a sophisticated and clinically grounded review of these evolving issues through expert-led discussions and practical diagnostic frameworks. For pathologists seeking deeper understanding of genomic integration, lymphoma classification, myeloid neoplasia, and complex hematopathology decision-making, this course offers a highly valuable educational resource aligned with the realities of modern diagnostic practice.

Basic & Clinical Immunology for the Busy Clinician 2025

Who Should Attend?

The educational series is directed to clinicians, nurses, and physician assistants caring for immune-mediated inflammatory diseases and integrative medicine, including rheumatology, allergy, immunology, gastroenterology, dermatology, pulmonology, and others.

Complete Immuno-Oncology Training | CAR T-Cell, Checkpoint Inhibitors & Toxicity Management

📌 Overview

The Memorial Sloan Kettering Cancer Center (MSKCC) Foundations in Immunotherapy 2026 is a comprehensive, evidence-based course designed to provide clinicians with a strong foundation in modern cancer immunotherapy.

This program covers the mechanisms, clinical applications, and toxicity management of immunotherapeutic agents across both solid tumors and hematologic malignancies, with a strong focus on real-world clinical practice.

Developed by experts at one of the world’s leading cancer centers, this course equips healthcare professionals with the knowledge needed to safely and effectively integrate immunotherapy into patient care .

📦 Course Specifications

• Videos: 23 HD lectures
• Subtitles: 23 VTT files
• PDFs: 20 supporting documents
• Total Size: 4.97 GB
• Format: On-demand learning
• Course Date: January 28, 2026

🎯 Target Audience

This course is ideal for:

• Medical oncologists
• Hematologists
• Oncology fellows and residents
• Nurse practitioners and physician assistants in oncology
• Multidisciplinary cancer care teams

🧠 What You Will Learn

🧬 Foundations of Immunotherapy

• Immune system mechanisms in cancer
• Innate vs adaptive immune responses
• Mechanisms of immune checkpoint blockade

💉 Checkpoint Inhibitors & Targeted Therapies

• PD-1, PD-L1, and CTLA-4 inhibitors
• Novel checkpoint inhibitors and combinations
• Clinical applications across multiple cancers

🧫 CAR T-Cell & Cellular Therapy

• CAR T-cell therapy principles and indications
• Patient selection and outcomes
• Toxicities: CRS, ICANS, cytopenias

🔬 Emerging Immunotherapies

• Bispecific antibodies (BiTEs)
• Tumor-infiltrating lymphocytes (TILs)
• Novel immune agonists and IL-2 agents

⚠️ Toxicity & Adverse Event Management

• Immune-related adverse events (irAEs)
• Pneumonitis, dermatologic toxicity, neurotoxicity
• Evidence-based management strategies

🧠 Clinical Application & Case-Based Learning

• Real-world case discussions
• Treatment planning and decision-making
• Personalized immunotherapy approaches

📚 Course Topics Include

• CAR T-cell therapy advancements
• Immunotherapy in leukemia, lymphoma, and myeloma
• Bladder, breast, melanoma, and GI cancers
• Small cell lung cancer immunotherapy
• Dermatologic and pulmonary toxicities
• Neurotoxicity and immune complications
• Bispecific immune-modulating agents
• Checkpoint inhibitor strategies

⚡ Key Benefits

• Master modern immunotherapy principles and applications
• Improve patient selection and treatment outcomes
• Recognize and manage serious immunotherapy toxicities
• Stay updated with latest oncology advances
• Apply knowledge directly in clinical practice

🚀 Why Choose This Course

• Developed by world-leading MSKCC experts
• Covers both foundations and advanced updates
• Focus on practical, real-world oncology care
• Essential for clinicians using or planning immunotherapy

💡 Clinical Value

This course is essential for healthcare professionals who want to:

• Integrate immunotherapy safely into oncology practice
• Improve outcomes in solid and hematologic cancers
• Stay current with rapidly evolving cancer treatments

🏥 About MSKCC

Memorial Sloan Kettering Cancer Center is one of the world’s leading cancer institutions, dedicated to advancing cancer treatment through research, education, and clinical excellence.

4. Topics

1. Advancing CAR T-Cell Strategies and Combination Therapies to Improve Outcomes in Gynecologic Malignancies

2. Advancing Leukemia Care Through Immuno-Oncology

3. Approaches to Immunotherapy-related Pneumonitis Management

4. Breast Oncology- Using cfDNA to Forecast Immunotherapy Treatment Outcomes

5. Checkpoint Inhibition as a Therapeutic Approach in Advanced Hodgkin Lymphoma

6. Clinical Approaches to Dermatologic Toxicity in Checkpoint Inhibitor Therapy

7. Discussion of Novel Checkpoint Inhibitors and Combination Therapy

8. Dostarlimab in MSI-High Gastrointestinal Cancers- Latest Data, Expansion Cohorts, and Basket Trial Insights

9. Evolving Treatment Paradigms- Immunotherapy in Advanced Bladder Cancer

10. IL-2-Stimulating Agents from Early Drug Development

11. Innovations in Small Cell Lung Cancer- DLL3 Agents and Adjuvant Durvalumab

12. Intrathecal Immunotherapy- A Novel Path in Treating Leptomeningeal Disease no video

13. Mechanism of Action of Checkpoint Blockade PD1, PDL1, CTLA-4

14. Melanoma Subtypes are a Microcosm for Immune Checkpoint Blockade Efficacy Across Oncology-

15. Neurotoxicity in CAR T-Cell Therapy- Recognition and Management

16. Overview of Adverse Events in the Cell Therapy Patient- A Discussion of CRS, ICANS, and Prolonged Cytopenias

17. Q&A and Discussion – 01

18. Q&A and Discussion – 02

19. Q&A and Discussion – 03

20. Q&A and Discussion – 04

21. Q&A and Discussion

22. Targeting Multiple Myeloma with Bispecific Immune-Modulating Agents

23. The Role of T-Cell Therapy in Standard Care for Synovial Sarcoma

24. Understanding Chimeric Antigen Receptor (CAR) T-Cell Therapy

Complete AP & CP Board Review (64 Videos + PDFs)

Prepare with confidence for pathology board exams with the Osler Pathology Virtual Review Spring 2026—one of the most comprehensive review programs covering Anatomic Pathology (AP) and Clinical Pathology (CP).

This intensive course delivers evidence-based lectures, board-focused concepts, and diagnostic frameworks designed to improve accuracy, confidence, and exam performance.

📦 Product Details

• Format: 64 Video Lectures (.MP4) + 64 Subtitle Files (.VTT) + 8 PDF Resources
• Total Size: 41.8 GB
• Course Dates: April 11–17, 2026
• Level: Intermediate to Advanced
• Access: Downloadable content

🔬 Program Overview

This structured review course provides a complete, high-yield overview of pathology, including:

• Anatomic Pathology (AP) – core diagnostic systems
• Clinical Pathology (CP) – lab medicine, hematology, microbiology
• Molecular and genetic testing integration
• Laboratory management and quality control

The course is organized for optimal learning:

• AP sessions: Saturday → Tuesday
• CP sessions: Tuesday → Friday
• Overlap day: Integrated AP + CP review

🎓 Key Features

• Full Board Review (AP + CP)
  Covers all major pathology domains
• Exam-Focused Learning
  Includes review questions and high-yield concepts
• Comprehensive e-Syllabus
  Includes slides and reference materials
• Structured Study Approach
  Helps identify weak areas and improve performance

📚 Learning Objectives

By completing this course, you will be able to:

• Formulate accurate differential diagnoses in pathology cases
• Apply guidelines from CAP, ASCP, and major organizations
• Interpret laboratory data and recommend further testing
• Understand transfusion medicine and blood bank practices
• Integrate molecular and genetic testing into clinical practice
• Improve diagnostic accuracy for board exams and real cases

📖 Topics Covered

🧬 Anatomic Pathology (AP)

• Dermatopathology, cytopathology, breast pathology
• GI, liver, pancreas, renal, and pulmonary pathology
• Neuropathology, cardiac pathology
• Pediatric and endocrine pathology
• Soft tissue, bone, and head & neck pathology

🧪 Clinical Pathology (CP)

• Blood bank and transfusion medicine
• Hematology (RBC, WBC, coagulation)
• Clinical chemistry (lipids, enzymes, diabetes)
• Immunology and flow cytometry
• Molecular pathology and cytogenetics

🦠 Microbiology

• Bacteriology, virology, mycology
• Parasitology and mycobacteriology
• Antibiotic sensitivity testing

⚙️ Lab Systems & Management

• Quality control and statistics
• Lab instrumentation and measurement
• Specimen handling and safety

👨‍⚕️ Who This Is For

• Pathology residents
• Practicing pathologists
• Physicians preparing for AP/CP board exams
• Laboratory medicine professionals

🚀 Why Choose This Course

• One of the most comprehensive pathology reviews available
• Designed specifically for board exam success (AP & CP)
• Covers both diagnostic pathology and lab medicine
• Improves clinical reasoning and interpretation skills
• Helps identify and strengthen weak knowledge areas

Expert Diagnostic Insights | APSS–USCAP Advanced Pathology Course

🎯 Product Description

Advance your diagnostic accuracy with USCAP Modern Surgical Pathology Through the Expert Eyes of APSS-USCAP – Seventh Edition 2026, a premier educational collaboration between United States and Canadian Academy of Pathology and Arthur Purdy Stout Society of Surgical Pathologists.

This high-yield course is specifically designed to address real-world diagnostic challenges in surgical pathology, focusing on common pitfalls that lead to errors and providing practical, evidence-based solutions.

Through expert-led lectures and case-based discussions, you’ll gain deeper insight into microscopic interpretation, immunohistochemistry, and molecular diagnostics, helping you make more accurate and confident diagnoses in daily practice.

📦 Course Details

• 📅 Release Date: March 17, 2026
• 🎥 Video Lectures + Subtitles
• 📄 Slide Handouts + Case-Based Materials
• 🧠 Multi-subspecialty surgical pathology coverage

👨‍⚕️ Target Audience

• Practicing Pathologists
• Pathology Residents & Fellows
• Academic & Community Pathologists

🧠 What You Will Master

✔️ Identification of diagnostic pitfalls in surgical pathology
✔️ Differentiation between reactive vs neoplastic lesions
✔️ Accurate evaluation of tumor invasion and classification
✔️ Effective use of immunohistochemistry (IHC)
✔️ Integration of molecular testing in diagnosis
✔️ Improved diagnostic confidence in complex cases

🧩 Core Topics Covered

🎀 Breast Pathology

• Challenging tumor differentials
• Diagnostic pitfalls & solutions

🍽 Gastrointestinal Pathology

• Inflammatory vs neoplastic conditions
• Upper GI diagnostic challenges

🚻 Genitourinary Pathology

• Tumor invasion assessment
• GU biopsy interpretation

👩‍⚕️ Gynecologic Pathology

• Reactive vs neoplastic changes
• Complex diagnostic scenarios

🧬 Soft Tissue Pathology

• Tumor classification
• Differential diagnosis strategies

🫁 Thoracic Pathology

• Lung neuroendocrine tumors
• Diagnostic nuances in thoracic specimens

🔬 Learning Approach

✔️ Case-based teaching with real diagnostic challenges
✔️ Practical algorithms for daily sign-out
✔️ Focus on microscopic + ancillary techniques
✔️ Evidence-based updates from expert faculty

💡 Key Features

✔️ Developed by world-leading pathology organizations
✔️ Focus on reducing diagnostic errors
✔️ Combines morphology, IHC, and molecular tools
✔️ Includes videos, slides, and case materials
✔️ Directly applicable to clinical practice

🚀 Why This Course?

Master difficult diagnostic scenarios
Reduce errors in daily pathology practice
Stay updated with modern classification systems
Learn from top international experts

👉 Essential course for modern surgical pathology practice